2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-109165AR
    Acoramidis hydrochloride (Standard) 2242751-53-5 98%
    Acoramidis hydrochloride (Standard) is the analytical standard of Acoramidis (hydrochloride) (HY-109165A). This product is intended for research and analytical applications. Acoramidis (AG10) hydrochloride is an orally active and selective Kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) hydrochloride is used in the study for transthyretin amyloidosis.
    Acoramidis hydrochloride (Standard)
  • HY-112540AR
    Acetoacetic acid lithium (Standard) 3483-11-2
    Acetoacetic acid (lithium) (Standard) is the analytical standard of Acetoacetic acid (lithium). This product is intended for research and analytical applications. Acetoacetic acid lithium is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid lithium induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid lithium can be used to study metabolic diseases.
    Acetoacetic acid lithium (Standard)
  • HY-113005AR
    Glutarylcarnitine lithium (Standard) 98%
    Glutarylcarnitine (lithium) (Standard) is the analytical standard of Glutarylcarnitine (lithium). This product is intended for research and analytical applications. Glutarylcarnitine lithium is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes.
    Glutarylcarnitine lithium (Standard)
  • HY-113016S1
    Elaidic acid-d17 98%
    Elaidic acid-d17 is deuterium labeled Elaidic acid. Elaidic acid is the major trans fat found in hydrogenated vegetable oils and can be used as a pharmaceutical solvent.
    Elaidic acid-d17
  • HY-113046S1
    5-Methyltetrahydrofolic acid-13C6 212248-92-5 98%
    5-Methyltetrahydrofolic acid-13C6 (5-Methyl THF-13C6) is 13C labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases.
    5-Methyltetrahydrofolic acid-13C6
  • HY-113071AR
    Mevalonic acid lithium salt (Standard) 2618458-93-6
    Mevalonic acid lithium salt (Standard) is the analytical standard of Mevalonic acid lithium salt. This product is intended for research and analytical applications. Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure.
    Mevalonic acid lithium salt (Standard)
  • HY-113097S1
    3α,7α-Dihydroxycoprostanic acid-d5 98%
    3α,7α-Dihydroxycoprostanic acid-d5 is deuterium labeled 3α,7α-Dihydroxycoprostanic acid. 3α,7α-Dihydroxycoprostanic acid is an endogenous metabolite. 3α,7α-Dihydroxycoprostanic acid, a bile acid, is the precursor to chenodeoxycholic acid.
    3α,7α-Dihydroxycoprostanic acid-d5
  • HY-113147S1
    L-Palmitoylcarnitine-d9 2847775-90-8 99.0%
    L-Palmitoylcarnitine-d9 is deuterium labeled L-Palmitoylcarnitine. L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.
    L-Palmitoylcarnitine-d9
  • HY-113165AR
    Isobutyryl-L-carnitine chloride (Standard) 6920-31-6
    Isobutyryl-L-carnitine (chloride) (Standard) is the analytical standard of Isobutyryl-L-carnitine (chloride). This product is intended for research and analytical applications. Isobutyryl-L-carnitine chloride is a product of the acyl-CoA dehydrogenases.
    Isobutyryl-L-carnitine chloride (Standard)
  • HY-113202S1
    Stearoyl-L-carnitine-d9 chloride 2936622-19-2 98%
    Stearoyl-L-carnitine-d9 chloride is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride, a fatty ester lipid molecule, is an endogenous metabolite. Stearoyl-L-carnitine chloride can be used as PKC inhibitor. Stearoyl-L-carnitine chloride accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoyl-L-carnitine chloride inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoyl-L-carnitine chloride acts as a metabolomics biomarker for Parkinson’s disease. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2.
    Stearoyl-L-carnitine-d9 chloride
  • HY-113432S2
    Nudifloramide-13C,d3
    Nudifloramide-13C,d3 (2PY-13C,d3) is the 13C- and deuterium labeled Nudifloramide (HY-113432). Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro.
    Nudifloramide-13C,d3
  • HY-121467S1
    Acotiamide-d4 98%
    Acotiamide-d4 (Z-338 (free base)-d4) is deuterium labeled Acotiamide. Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
    Acotiamide-d4
  • HY-125138S1
    ω-Muricholic acid-d4 98%
    ω-Muricholic acid-d4 (ω-MCA-d4) is deuterium labeled ω-Muricholic Acid. ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.
    ω-Muricholic acid-d4
  • HY-126042S4
    (±)-Lisofylline-d4 1185879-05-3 98%
    (±)-Lisofylline-d4 ((±)-Lisophylline-d4) is deuterium labeled (±)-Lisofylline. (±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research.
    (±)-Lisofylline-d4
  • HY-127035S4
    Tristearin-d9 285979-76-2 98%
    Tristearin-d9 is the deuterium labeled Tristearin (HY-127035). Tristearin is a triglyceride derived from three units of stearic acid.
    Tristearin-d9
  • HY-129283BR
    Goralatide acetate (Standard)
    Goralatide (acetate) (Standard) is the analytical standard of Goralatide (acetate). This product is intended for research and analytical applications. Goralatide, a natural tetrapeptide, is a physiological regulator of hematopoiesis. Goralatide can inhibit primitive haematopoietic cell proliferation.
    Goralatide acetate (Standard)
  • HY-129380AR
    Fructosyl-lysine dihydrochloride (Standard) 96192-35-7 98%
    Fructosyl-lysine (dihydrochloride) (Standard) is the analytical standard of Fructosyl-lysine (dihydrochloride). This product is intended for research and analytical applications. Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine-arginine protein cross-link that can be an indicator in diabetes detection.
    Fructosyl-lysine dihydrochloride (Standard)
  • HY-130569S1
    7-Hydroxymethotrexate-d3 432545-62-5 98%
    7-Hydroxymethotrexate-d3 is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
    7-Hydroxymethotrexate-d3
  • HY-132489S1
    (Rac)-Sitagliptin-d4-1 hydrochloride 2749855-96-5
    (Rac)-Sitagliptin-d4-1 hydrochloride ((Rac)-MK-0431-d4-1 hydrochloride) is the deuterium labeled (Rac)-Sitagliptin-1 hydrochloride. (Rac)-Sitagliptin is an isoform of Sitagliptin (HY-13749), which is a potent and orally active inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts.
    (Rac)-Sitagliptin-d4-1 hydrochloride
  • HY-133890AS
    Tauro-α-muricholic acid-d4 sodium 98%
    Tauro-α-muricholic acid-d4 (sodium) is the deuterium labeled Tauro-α-muricholic acid sodium (HY-133890A). Tauro-α-muricholic acid sodium (T-α-MCA sodium) is a Taurine (HY-B0351)-conjugated primary Bile acid. Tauro-α-muricholic acid sodium is a FXR antagonist with an IC50 of  28 µM. Tauro-α-muricholic acid sodium attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid sodium can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism.
    Tauro-α-muricholic acid-d4 sodium
Cat. No. Product Name / Synonyms Application Reactivity